EP.09 / Mark Zajdzinski AIA, DBIA, SmithGroup on the Caltech Chen Neuroscience Research Building


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A home for Nobel Prize winners and the center for research that is helping push humanity forward, the Chen Neuroscience building is a fascinating academic and research hub in Pasadena. Mark Zajdzinski describes how his team at SmithGroup designed and delivered this building for Caltech.

In this episode I am joined by Mark Zajdzinski, a Principal at SmithGroup, to discuss the award-winning California Institute of Technology's Chen Neuroscience Research Building in Pasadena. The building is on the corner of Wilson and Del Mar and serves as an administrative hub for the Division of Biology and Bioengineering with research disciplines focused on brain development and treatments. We dive into Mark's passion for the project, the team's commitment to sustainability, and how Mark's global studies influence his perspective on architecture. 

Throughout our conversation, we explore the intentional design choices which encourage collaboration among the various types of researchers. We also touch on the challenges of building complex neuroscience labs, and how Mark’s team created adaptable and flexible lab spaces which can evolve over time as needs and technologies change.

Plus, Mark reflects on his early career at SCI-Arc and the joys of being a participant in Greg Walsh's Japan Studio program, highlighting the connections between Japanese architecture and the eclectic nature of Los Angeles. He talks about his influences, the people who've inspired him the most, and the rewards of creating spaces that help shape our collective future.



About Mark Zajdzinski, AIA, DBIA, NCARB

Mark brings over 20 years of technical and management leadership, having an array of project experience from workplace, healthcare, Science + Tech, mixed-use and high-rise buildings. He is an active member in collaborative team efforts having worked on several Design-Build projects. Mark’s been an integral part of the project teams providing intuitive leadership and technical advice.

He is a graduate of Southern California Institute of Architecture and is a Principal at SmithGroup in Los Angeles. He was the Project architect on the Tianqiao & Chrissy Chen Neuroscience Research Building at Caltech which won the 2021 DBIA Western Pacific Region - Project of the Year + Design Excellence Awards. His technical and management ability adds a robustness to project teams; while his passion for architecture comes from the impact the buildings he works on contribute to the overall health of its inhabitants. 

Connect with Mark on LinkedIn



Topics Covered

  • Designing a space that encourages interactions between all types of scientists and engineers 

  • Using natural light to create a sense of balance and homey atmosphere 

  • How SmithGroup approached the initial massing of the project 

  • The initial goals for the sustainability of the building 

  • How they were awarded the project and worked with multiple collaborators 

  • Mark’s experience studying with Greg Walsh in his Japan Studio program

  • How Mark’s studies in Japan and the Galapagos influenced his perspective on architecture 

  • Why Mark was attracted to work at SmithGroup

  • The skills necessary for architects to design complex science buildings

  • What inspires Mark about working in LA   


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EP.10 / David Kuo, Fatty Corp and Catherine Johnson AIA, ACLA, Design, Bitches on Fatty Mart

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EP.08 / Patricia Rhee, FAIA, DBIA, EYRC Architects on The Culver Steps